Aprotinin in cardiac surgery patients: is the risk worth the benefit?
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چکیده
منابع مشابه
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متن کاملAprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients
Background—Aprotinin is frequently used in high-risk cardiac surgery patients to decrease bleeding complications and transfusions of packed red blood cells (PRBC). Transfusions of PRBC are known to directly increase the risk of new onset postoperative renal failure (ARF) in cardiac surgery patients. A recent highly publicized report implicated aprotinin as an independent causal factor for posto...
متن کاملAprotinin and lysine analogues in high-risk cardiac surgery.
BACKGROUND Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences. METHODS In this multicenter, blinded trial, we randomly assigned ...
متن کاملA disheartening story: Aprotinin in cardiac surgery
Results: In propensity-adjusted, multivariable logistic regression (C-index, 0.72), use of aprotinin was associated with a doubling in the risk of renal failure requiring dialysis among patients undergoing complex coronary-artery surgery (odds ratio, 2.59; 95 percent confidence interval, 1.36 to 4.95) or primary surgery (odds ratio, 2.34; 95 percent confidence interval, 1.27 to 4.31). Similarly...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2009
ISSN: 1010-7940
DOI: 10.1016/j.ejcts.2009.04.053